We do, however, have a framework of references regarding the other natural mysteries humans once ascribed to gods having elegant solutions rooted in the hard sciences. We searched the storm clouds and didn’t find Thor. We’ve dug boreholes and didn’t find Hades. We’ve studied the sun and haven’t found Ra. Human history is chock full of gods and “higher powers” to explain the unknown, and as we learned more about the world the less relevant they became. We learned sacrificing goats to a god does not make it rain, and now understand the natural and mundane systems that do. There’s no reason to believe that the creation of matter or “something from nothing” as you put it is any different.